Genprex said research conducted with Meharry Medical College on TUSC2, the tumor-suppressor gene used in its cancer candidate REQORSA, will be presented at the Gerontological Society of America’s annual meeting on Nov. 4. The work examines links between TUSC2, cell resilience, mitochondrial biology and aging-related processes.
The announcement is a research update, not a change to Genprex’s clinical programs or a report of a new treatment. The company says the collaboration may help it explore applications beyond oncology, but further research is needed to assess whether the findings could support therapeutic development.
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What will be presented: The poster is titled “TUSC2 Gene Therapy in Humans Induces a Cellular-Resilience Program.” It is scheduled for the meeting’s Late Breaking Poster Session I, from 6 to 7:15 p.m. ET on Nov. 4, at the Gaylord National Resort & Convention Center in National Harbor, Maryland. Genprex Chief Medical Officer Mark S. Berger will present it.
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Research focus: The work investigates REQORSA’s biological activity, including its possible effects on mitochondrial metabolism, cellular stress responses and molecular processes associated with aging. REQORSA, also called quaratusugene ozeplasmid, is designed to deliver the TUSC2 gene and restore tumor-suppressor function.
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Collaboration and next steps: Genprex began its sponsored research collaboration with Meharry in 2024 and is working with the college to broaden the research into aging-related biology. The announcement did not provide the study’s underlying results or details about the research methods.
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Where it fits: Genprex said it is continuing to prioritize development in lung cancer and diabetes while exploring whether TUSC2 biology could have relevance beyond oncology.
The poster title points to a finding involving human research, but the announcement provides no data to assess its significance or whether it indicates a potential clinical benefit. Genprex said additional research will be needed before the work could inform a therapeutic application.